Summary
Description
Leiomyoma of deep soft tissue is a rare benign soft tissue tumor that occurs in the deep subcutaneous tissues or in skeletal muscle of the extremities.
People and Age
The sexes are equally affected.
Symptoms and Presentation
A slow growing mass with minimal tenderness.
Brief description of the xray
Calcifications are frequently present within the lesion.
Brief desc of tx
Local, complete excision ( marginal margin) is curative.
Tumor Name
Tumor Type
Benign or Malignant
Body region
Most Common Bones
Complete Information on this Tumor
Introduction and Definition
Leiomyoma of deep soft tissue is a very rare, benign soft tissue tumors that arise in the deep subcutaneous tissues or in skeletal muscle. The sexes are equally affected. The tumor occurs most commonly in the extremities.
Incidence and Demographics
The tumor is very rare. Based on the small number of cases in the literature, men and women are equally affected. the age at diagnosis may be from 14 to 62 years, mean 37 years.
Symptoms and Presentation
A slow growing, minimally painful mass in the deep subcutaneous tissues of the extremities.
X-Ray Appearance and Advanced Imaging Findings
The soft tissue lesion may have amorphous calcifications.
Differential Diagnosis
Synovial sarcoma, ancient schwannoma, low grade leiomyosarcoma
Preferred Biopsy Technique for this Tumor
open
Histopathology findings
The tumors are well-defined and have a pseudocapsule. The cells are spindle shaped and appear in intersecting fascicles. The nuclei are elongated with rounded ends, and the cytoplasm is tapered and eosinophilic. Mitotic figures are very rare, less than one per 50 HPF's. There may be hyaline or myxoid stroma with degeneration. There may be nodules resembling necrobiotic granuloma or giant rosettes. Immunohistochemical staining is positive for desmin in all cases.
Treatment Options for this Tumor
Marginal excision is curative.
Preferred Margin for this Tumor
Marginal
Outcomes of Treatment and Prognosis
Complete excision is associated with a low likelihood of recurrence. Prognosis is excellent with appropriate treatment.
Special and Unusual Features
A very rare tumor, with around twenty cases in the worldwide literature.
Suggested Reading and Reference
Leiomyoma of deep soft tissue. Clinicopathologic analysis of a series.
Kilpatrick SE, Mentzel T, Fletcher CD.
Am J Surg Pathol. 1994 Jun;18(6):576-82.
Do leiomyomas of deep soft tissue exist? An analysis of highly differentiated smooth muscle tumors of deep soft tissue supporting two distinct subtypes.
Billings SD, Folpe AL, Weiss SW.
Am J Surg Pathol. 2001 Sep;25(9):1134-42.
Kilpatrick SE, Mentzel T, Fletcher CD.
Am J Surg Pathol. 1994 Jun;18(6):576-82.
Do leiomyomas of deep soft tissue exist? An analysis of highly differentiated smooth muscle tumors of deep soft tissue supporting two distinct subtypes.
Billings SD, Folpe AL, Weiss SW.
Am J Surg Pathol. 2001 Sep;25(9):1134-42.
